We recommend setting your Kayak alerts early - airfairs are low at the moment but with summer being high season you could see tickets prices go up by March / April. You'll need to fly into Paris Charles de Gaulle (CDG) or Paris Orly (ORY). What's the difference between the two? Not much - think JFK (CDG) vs. La Guardia (ORY) - ORY, on the Southern outskirt, is closer to the Paris city center but not as many international flights go in and out.
Tours Airport (TUF) is a small airport in the Loire Valley - you won't be able to fly from the States but if you're planning on traveling to/from London, Dublin, Marrakesh or Porto - it might be a good idea to explore flight options there through with RyanAir.
Getting to the venue
The Loire Valley is located in Central France, approximately 2:30hr south of Paris. To get to the venue, we highly recommend renting a car - it's the most economical way of getting to the venue, if you're traveling with others, and gives you the flexibly of getting around. Driving in France might sound intimidating but trust us, it's not that complicated - same signage, same side of the road, just a few extra roundabouts.